Pharmacological similarities between native brain and heterologously expressed a4b2 nicotinic receptors
نویسندگان
چکیده
Division of Biomedical Sciences, University of California, Riverside, California, CA 92521-0121, U.S.A. Department of Environmental Toxicology, University of California, Riverside, California, CA 92521-0121, U.S.A.; Elan Pharmaceuticals, 3760 Haven Ave., Menlo Park, CA 94025-1012, U.S.A. and Pharmacology & Experimental Therapeutics, College of Pharmacy, University of Kentucky, Lexington, Kentucky, KY 40536-0082, U.S.A.
منابع مشابه
AT-1001 Is a Partial Agonist with High Affinity and Selectivity at Human and Rat a3b4 Nicotinic Cholinergic Receptors
AT-1001 [N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1] nonan3-amine] is a high-affinity and highly selective ligand at a3b4 nicotinic cholinergic receptors (nAChRs) that was reported to decrease nicotine self-administration in rats. It was initially reported to be an antagonist at rat a3b4 nAChRs heterologously expressed in HEK293 cells. Here we compared AT-1001 actions at rat and humana3b4 an...
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